HVEM costimulatory domain boosts CAR T cell efficacy against solid tumors via enhanced TRAF-mediated TNF signaling

HVEM enhances CAR T cell efficacy against solid tumors by robustly activating TNF signaling through TRAF recruitment, particularly via the AVEE motif. These findings highlight HVEM as a promising co-stimulatory domain for improving CAR T cell therapy in solid tumors, with implications for metabolic reprogramming and sustained antitumor activity.

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Publication Details

Journal
Cell Communication and Signaling
Published
2026-01-08
DOI
https://doi.org/10.1186/s12964-025-02648-4
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00
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article

HVEM costimulatory domain boosts CAR T cell efficacy against solid tumors via enhanced TRAF-mediated TNF signaling

Yizhou Yao, Haiheng Xu, Shishuo Sun, Xiaoge Gao et al.
Cell Communication and Signaling
CAR-T cell therapy research
article

HVEM costimulatory domain boosts CAR T cell efficacy against solid tumors via enhanced TRAF-mediated TNF signaling

Yizhou Yao, Haiheng Xu, Shishuo Sun, Xiaoge Gao, Wanxin Zhao, Xiaoxiao Liu, Junnian Zheng, Patrick Ming-Kuen Tang, Zhenyu Wang, Ying Xue, Yibing Liang, Qing Zhang, Yifan Yuan, Qihong Li, Hailong Li
article en

Abstract

HVEM enhances CAR T cell efficacy against solid tumors by robustly activating TNF signaling through TRAF recruitment, particularly via the AVEE motif. These findings highlight HVEM as a promising co-stimulatory domain for improving CAR T cell therapy in solid tumors, with implications for metabolic reprogramming and sustained antitumor activity.

Cell Communication and SignalingVol. 24(1)
Jiangsu University (CN), Xuzhou Medical College (CN), Chinese University of Hong Kong (HK), Soochow University (CN), Xuzhou Cancer Hospital (CN), First Affiliated Hospital of Soochow University (CN)
Good health and well-being
Openalex Percentile: Top 97%
CAR-T cell therapy research
DOIOpen Access PDFOpenAlex
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HVEM costimulatory domain boosts CAR T cell efficacy against solid tumors via enhanced TRAF-mediated TNF signaling — Yizhou Yao, Haiheng Xu, et al. · Cell Communication and Signaling (2026) | TGRS Research Map | TGRS