Integrating chromosome 19 local ancestry in genetic‐regional association studies reveal novel ancestry‐specific variants associated with hippocampal volume and CSF‐Aβ42
This study advances the understanding of genetic variation in AD. The findings support the inclusion of local ancestry analysis as a critical component of future AD genetic research, promoting equity in genetic discovery and personalized medicine.
Authors
- Hieab H.H. Adams (ORCID: https://orcid.org/0000-0003-3687-2508)
- Blanca Rodríguez‐Fernández (ORCID: https://orcid.org/0000-0002-5664-111X)
- Federica Anastasi (ORCID: https://orcid.org/0000-0002-9304-5421)
- Tavia E. Evans (ORCID: https://orcid.org/0000-0003-2390-286X)
- Patricia Genius (ORCID: https://orcid.org/0000-0003-1836-5123)
- Natàlia Vilor‐Tejedor (ORCID: https://orcid.org/0000-0003-4935-6721)
- Arcadi Segura i Navarro
- Carolina Minguillón (ORCID: https://orcid.org/0000-0002-2782-6908)
- Elizabeth Chudleigh
- Manel Esteller
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Radboud University Nijmegen (NL)
- Trinity College Dublin (IE)
- Adolfo Ibáñez University (CL)
- Instituto de Salud Carlos III (ES)
- Radboud University Medical Center (NL)
- Escuela Nacional de Sanidad (ES)
- Josep Carreras Leukaemia Research Institute (ES)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Institut de Biologia Evolutiva (ES)
- Centre for Genomic Regulation (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105451
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00