Cerebrolysin, hemorrhagic transformation, and anticoagulation timing after reperfusion therapy in stroke: post hoc secondary analysis of the CEREHETIS trial

In IVT-treated MCA stroke patients with HTI 1-4, Cerebrolysin may reduce HT hazard and advance the risk-equilibrium point by approximately 1-2 days. These findings are preliminary and hypothesis-generating, suggesting that Cerebrolysin may allow earlier-but individualized-anticoagulation resumption in selected high-risk patients, pending prospective validation.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-01-07
DOI
https://doi.org/10.3389/fphar.2025.1725255
Primary Topic
Neurological Disorders and Treatments
Type
article
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article

Cerebrolysin, hemorrhagic transformation, and anticoagulation timing after reperfusion therapy in stroke: post hoc secondary analysis of the CEREHETIS trial

Д. Р. Хасанова, Mikhail N. Kalinin
Frontiers in Pharmacology
Neurological Disorders and Treatments
article

Cerebrolysin, hemorrhagic transformation, and anticoagulation timing after reperfusion therapy in stroke: post hoc secondary analysis of the CEREHETIS trial

Д. Р. Хасанова, Mikhail N. Kalinin
article en

Abstract

In IVT-treated MCA stroke patients with HTI 1-4, Cerebrolysin may reduce HT hazard and advance the risk-equilibrium point by approximately 1-2 days. These findings are preliminary and hypothesis-generating, suggesting that Cerebrolysin may allow earlier-but individualized-anticoagulation resumption in selected high-risk patients, pending prospective validation.

Frontiers in PharmacologyVol. 16
Kazan State Medical University (RU), State Autonomous Institution of Health Interregional Clinical Diagnostic Center (RU)
Good health and well-being
Openalex Percentile: Top 96%
Neurological Disorders and Treatments
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