Dual anti-pseudomonal and resistance-modulatory actions of <i>Sida acuta</i> (Malvaceae) via BamB–OprM targeting: insights from integrated metabolomics, computational, and <i>in vitro</i> analyses
These findings establish a mechanistic basis for translating ethnopharmacology into therapeutic strategies against MDR Gram-negative pathogens. Future work should prioritize <i>in vivo</i> validation and preclinical optimization of lead dual-target adjuvants.
Authors
- Mingquan Guo (ORCID: https://orcid.org/0000-0002-8236-3256)
- Victor Kuete (ORCID: https://orcid.org/0000-0002-1070-1236)
- Hélène Gueaba Mbuntcha (ORCID: https://orcid.org/0009-0007-2738-9916)
- Armel Jackson Seukep
- Cromwel Tepap Zemnou
- Arnaud Fondjo Kouam
Institutions
- University of Buea (CM)
- Université de Dschang (CM)
- Zhejiang Business Technology Institute (CN)
- Euro-Mediterranean University of Fes (MA)
- Ningbo Institute of Industrial Technology (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1080/13880209.2025.2611594
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 45.17