Real‐World Performance of <scp>CSF</scp> Kappa Free Light Chains in the 2024 <scp>McDonald</scp> Criteria

In the setting of the 2024 McDonald criteria, KFLC metrics correcting for the CSF/serum albumin quotient were equivalent to OCBs. The intrathecal fraction provided no advantage over the KFLC index, which is simpler to compute. Importantly, the KFLC index can replace OCB when CSF positivity is essential for diagnosis. We provide an explanation for KFLC's comparable diagnostic performance despite its inability to identify CSF-only clones.

Authors

Institutions

Publication Details

Journal
Annals of Clinical and Translational Neurology
Published
2026-01-07
DOI
https://doi.org/10.1002/acn3.70300
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

M. Bonello, Stefania Kaninia, Maya Leibowitz, Victor Iliev et al.
Annals of Clinical and Translational Neurology
Multiple Sclerosis Research Studies
article

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

M. Bonello, Stefania Kaninia, Maya Leibowitz, Victor Iliev, Will Greenway, Ryan Cooper, Kathryn Challis, Ian Galea, Deborah T. Shode, Mahmoud Elbahnasawi, Alison M. E. Whitelegg, Dominika Gajdasik
article en

Abstract

In the setting of the 2024 McDonald criteria, KFLC metrics correcting for the CSF/serum albumin quotient were equivalent to OCBs. The intrathecal fraction provided no advantage over the KFLC index, which is simpler to compute. Importantly, the KFLC index can replace OCB when CSF positivity is essential for diagnosis. We provide an explanation for KFLC's comparable diagnostic performance despite its inability to identify CSF-only clones.

Annals of Clinical and Translational Neurology
Dorset HealthCare University NHS Foundation Trust (GB), University Hospital Southampton NHS Foundation Trust (GB), Thermo Fisher Scientific (United Kingdom) (GB), Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust (GB), University of Southampton (GB)
National Institute for Health and Care Research
Openalex Percentile: Top 97%
Multiple Sclerosis Research Studies
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Real‐World Performance of <scp>CSF</scp> Kappa Free Light Chains in the 2024 <scp>McDonald</scp> Criteria — M. Bonello, Stefania Kaninia, et al. · Annals of Clinical and Translational Neurology (2026) | TGRS Research Map | TGRS