The food grade bacterium Lactobacillus helveticus VEL12193 promotes autophagy by releasing membrane vesicles
In this study, we present evidence that intervention with ferments/probiotics stimulates autophagy in multiple cell types and organs, and we show in vitro that MVs mediate this effect. Additionally, we identify L. helveticus VEL12193 as a promising candidate for the development of healthy-aging strategies.
Authors
- Niyazi Acar (ORCID: https://orcid.org/0000-0002-3401-8079)
- Élise Jacquin (ORCID: https://orcid.org/0000-0003-0368-4113)
- Jana Al Azzaz
- Marie-Agnès Bringer (ORCID: https://orcid.org/0000-0002-3746-4998)
- Catherine Daniel (ORCID: https://orcid.org/0000-0002-5299-2799)
- Julia Novion Ducassou (ORCID: https://orcid.org/0000-0002-2243-8308)
- Bénédicte Buteau
- Guilhem Faure (ORCID: https://orcid.org/0000-0001-9537-2277)
- Lil Proukhnitzky
- Yohann Couté (ORCID: https://orcid.org/0000-0003-3896-6196)
- Amaury Aumeunier
- Jean-Paul Pais de Barros
- Simon Manceau
- Florian Chain
- Luis G. Bermúdez-Humarán
- Pierre Lapaquette
- Aurélie Rieu
- Zandile Mlamla
Institutions
- Broad Institute (US)
- Centre National de la Recherche Scientifique (FR)
- McGovern Institute for Brain Research (US)
- Inserm (FR)
- Université de Bourgogne (FR)
- Université de Lille (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- CEA Grenoble (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Center for Infection and Immunity of Lille (FR)
- Institut Agro Dijon (FR)
- Centre des Sciences du Goût et de l'Alimentation (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s12964-025-02616-y
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00