Micro Albuminuria as an Indicator of IBD Activity

Background: Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic, relapsing, and remitting inflammatory disorder of the gastrointestinal tract. This study aimed to assess microalbuminuria role in IBD activity prediction and to investigate the correlation between microalbuminuria with disease activity. Methods: This a case control study involved 50 IBD adult cases at Benha University Hospitals. Patients were divided into two groups: Group A (n=40): Patients had IBD that subdivided according to the disease activity into two equal groups: Group A1 (n=20): Active group, group A2 (n=20): Remission group and group B (n=10): people were healthy controls group. Results: There was a significant correlation between microalbuminuria and UC (r=0.807, P< 0.001) and CD (r=0.652, p<0.001), CRP (r=0.834, P< 0.001), ESR (r=0.837, P< 0.001) and fecal calprotectin antigen (FCP) (r=0.854, P< 0.001). There was an insignificant correlation between microalbuminuria and serum creatinine and GFR. Conclusion: It can be concluded that microalbuminuria is significantly elevated in patients with IBD, particularly during active disease. It was strongly related to established markers of inflammation and disease activity, including CRP, ESR, FCP and disease activity scores.