BMP4 dose dictates lineage specification bias in human periodontal ligament stem cells
These findings demonstrate that precise BMP4 dosage regulation dictates PDLSC differentiation outcomes, providing crucial insights for optimizing PDLSC-based periodontal regenerative therapies.
Authors
- Jennifer Zhang
- Fuhua Yan
- Qi Tang (ORCID: https://orcid.org/0000-0001-9614-1075)
- Cheng-Yu Lin
- Y. Li
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
- M B Lin
- Minhui Guo
Institutions
- Fujian Normal University (CN)
- Tulane University (US)
- Fujian Medical University (CN)
- Stomatology Hospital (CN)
- Fujian Provincial Hospital (CN)
- University at Buffalo, State University of New York (US)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fbioe.2025.1738051
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Fujian Normal University
- Fujian Medical University