Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial

Both RYGB and OAGB lead to markedly enhanced postprandial GLP-1 responses, with no corresponding change in secretin levels. RYGB produces higher early postprandial increases in GLP-1 and glucose than OAGB, demonstrating that procedural differences can influence gut hormone and glucose responses.

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Publication Details

Journal
International Journal of Obesity
Published
2026-01-06
DOI
https://doi.org/10.1038/s41366-025-02000-3
Primary Topic
Bariatric Surgery and Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial

P. Johan Groop, J. E. Karppinen, T. Saarinen, A. Juuti et al.
International Journal of Obesity
Bariatric Surgery and Outcomes
article

Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial

P. Johan Groop, J. E. Karppinen, T. Saarinen, A. Juuti, J. J. Holst, S. Heinonen, K. H. Pietiläinen
article en

Abstract

Both RYGB and OAGB lead to markedly enhanced postprandial GLP-1 responses, with no corresponding change in secretin levels. RYGB produces higher early postprandial increases in GLP-1 and glucose than OAGB, demonstrating that procedural differences can influence gut hormone and glucose responses.

International Journal of Obesity
University of Helsinki (FI), Helsinki University Hospital (FI), Novo Nordisk Foundation (DK), Institute for Molecular Medicine Finland (FI), Folkhälsans Forskningscentrum (FI), Hospital District of Helsinki and Uusimaa (FI)
Good health and well-being
Openalex Percentile: Top 97%
Bariatric Surgery and Outcomes
DOIOpen Access PDFOpenAlex
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Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial — P. Johan Groop, J. E. Karppinen, et al. · International Journal of Obesity (2026) | TGRS Research Map | TGRS