Regenerative Index reveals declining muscle regeneration in paediatric patients with Duchenne muscular dystrophy
Using eMHC and IgG immunostaining to calculate RI accurately assesses regeneration despite the variation in histopathologic severity between biopsies. This methodology demonstrated a significant negative correlation between RI and age of DMD boys from 7 to 11 years of age.
Authors
- Johnathan K. Smid
- Steven A. Moore (ORCID: https://orcid.org/0000-0002-6353-7900)
- Michael A. Rudnicki (ORCID: https://orcid.org/0000-0002-3866-5249)
- Jacob Monast
- Charis A. McPherson
- Shanti S. S. Rayagiri
Institutions
- University of Iowa (US)
- University of Ottawa (CA)
- Ottawa Hospital (CA)
- Systems, Applications & Products in Data Processing (Canada) (CA)
- Ottawa Hospital Research Institute (CA)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-05
- DOI
- https://doi.org/10.64898/2026.01.05.697715
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Ottawa