Redefinition of the toll-like receptor repertoire in Ciona robusta through genomic, structural, and expression analyses
Our findings revise the repertoire of bona fide TLRs in <i>Ciona</i> to three (CiTLR1, CiTLR2, CiTLRs1) and emphasize the risk of overestimating TLR diversity based solely on sequence homology without domain and functional validation. This work refines the structural and functional landscape of ascidian TLRs.
Authors
- Larry J. Dishaw (ORCID: https://orcid.org/0000-0002-2705-4573)
- Shin Matsubara (ORCID: https://orcid.org/0000-0002-7794-534X)
- Sakura Kikuchi
- Kanako Hisata (ORCID: https://orcid.org/0000-0002-6313-3340)
- Noriyuki Satoh
- Akira Shiraishi
- Honoo Satake
Institutions
- Okinawa Institute of Science and Technology Graduate University (JP)
- Suntory Foundation for Life Sciences (JP)
- University of South Florida St. Petersburg (US)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fcimb.2025.1716256
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Okinawa Institute of Science and Technology Graduate University
- Japan Society for the Promotion of Science