Ubiquitin specific peptidase 8 mediates angiotensin-II-induced smooth muscle cell phenotypic transformation during hypertension via regulating LRRC8A
LRRC8A upregulation involves in SMC phenotypic transformation under the hypertension context; USP8 can modulate LRRC8A expression in a deubiquitination-dependent manner to further regulate the downstream PI3K/AKT axis during hypertension, which may provide novel therapeutic targets for hypertension management.
Authors
- Liang Liu (ORCID: https://orcid.org/0000-0003-3020-1367)
- Guangrui Feng
- Ge Xiong (ORCID: https://orcid.org/0009-0006-6667-5344)
- Huiliang Zhou
Institutions
- Xianning Central Hospital (CN)
Publication Details
- Journal
- American Journal of Hypertension
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1093/ajh/hpaf250
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00