Aerobic exercise training attenuates cardiac inflammation and fibrosis in mice with type 2 diabetes and inhibits the advanced glycation end products pathway
Aerobic exercise mitigates cardiac changes in T2D by downregulating the AGE signaling pathway and reducing fibrosis and inflammation. These findings highlight the therapeutic potential of exercise in interfering with AGE-mediated mechanisms to alleviate T2D-associated cardiovascular complications.
Authors
- Beatriz Peres de Araujo
- Karine Lino Rodrigues (ORCID: https://orcid.org/0000-0002-6463-0285)
- Vivian Vieira Dias Da Silva
- Evelyn Nunes Goulart da Silva Pereira (ORCID: https://orcid.org/0000-0001-5511-7036)
- Raquel Rangel Silvares
- Juliana M. C. Barbosa (ORCID: https://orcid.org/0000-0002-4326-3260)
- Anissa Daliry (ORCID: https://orcid.org/0000-0001-7303-0030)
- Daniel Olindo de Castro-Linhares
Institutions
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s13098-025-02076-x
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00