CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice
These findings suggest that CHI3L1 monoclonal antibody therapy may attenuate cognitive decline in AD by modulating neuroinflamma.
Authors
- Sang-Bae Han
- J S Kim
- Min Ki Choi
- Yong Sun Lee (ORCID: https://orcid.org/0000-0003-4616-2622)
- Jaesuk Yun
- Dong Ju Son
- Tae Hun Kim
- Hye Jin Lee
- Hyeon Joo Ham
- Hanseul Park
- Key-Hwan Lim
- Jin Tae Hong
- Seung Sik Park
Institutions
- Chungbuk National University (KR)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fnmol.2025.1728279
- Primary Topic
- Studies on Chitinases and Chitosanases
- Type
- article
- Field-Weighted Citation Impact
- 0.00