CD99Targeted Irinotecan Containing Nanoparticles Show Twenty-Fold Greater Anti-Tumor Effect Than Free Irinotecan For Treatment of Ewing Sarcoma
NV103 displays potent and durable antitumor activity in Ewing sarcoma at low doses with no toxicity and favorable pharmacokinetics. These findings support further development for clinical translation.
Authors
- Sheetal A. Mitra (ORCID: https://orcid.org/0000-0002-6110-2161)
- Bryon Upton
- Jon O. Nagy (ORCID: https://orcid.org/0009-0009-6212-6091)
- Jean Hugues Parmentier
- Timothy Triche
- Hyung Gyoo Kang
- Anahit Hovsepyran
Institutions
- Nanzan University (JP)
- Children's Hospital of Los Angeles (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-06
- DOI
- https://doi.org/10.64898/2026.01.06.697855
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00