Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes
Our analyses suggest cardiovascular and metabolic consequences of statin usage are on different causal pathways, and hence could be influenced separately by targeted interventions. More broadly, our analysis workflow offers potential insights to identify pathway-specific causal risk factors that could provide possible repositioning or refinement opportunities for existing drug targets.
Authors
- John C. Whittaker (ORCID: https://orcid.org/0000-0002-3529-2379)
- Ville Karhunen (ORCID: https://orcid.org/0000-0001-6064-1588)
- Seongwon Hwang (ORCID: https://orcid.org/0000-0003-0805-3708)
- Stephen Burgess (ORCID: https://orcid.org/0000-0001-5365-8760)
- Sam M Lockhart
- Ashish Patel
- Paul Carter
Institutions
- Queen's University Belfast (GB)
- University of Cambridge (GB)
- Wellcome/MRC Institute of Metabolic Science (GB)
- MRC Biostatistics Unit (GB)
Publication Details
- Journal
- International Journal of Epidemiology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1093/ije/dyaf223
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Department of Health, Northern Ireland
- British Heart Foundation
- Queen's University Belfast
- Queen's University
- Medical Research Council