Outside Back Cover: Rhodopsin‐Mimicking Reversible Photo‐Switchable Chloride Channels Based on Azobenzene‐Appended <i>Semiaza</i> ‐Bambusurils for Light‐Controlled Ion Transport and Cancer Cell Apoptosis (Angew. Chem. Int. Ed. 3/2026)
In the Research Article (e202519101), Tengfei Yan, Ofer Reany, Junqiu Liu, and co-workers present a reversible, light-controlled ON/OFF chloride channel based on azobenzene-functionalized semiaza-bambus[6]urils. These biomimetic systems achieve stimulus-responsive chloride transport through photoisomerization, demonstrating unprecedented controllability in both liposomal membranes and living cells. The (E)-isomer selectively enables chloride flux, induces significant mitochondrial and lysosomal disruption, and promotes apoptosis in cancer cells, while the (Z)-isomer remains inactive.
Authors
- Canhong Zhu
- Yuancheng Ji (ORCID: https://orcid.org/0000-0002-7864-9008)
- Ofer Reany (ORCID: https://orcid.org/0000-0003-1048-1947)
- Tengfei Yan (ORCID: https://orcid.org/0000-0003-4797-0808)
- Yang Zhang (ORCID: https://orcid.org/0000-0002-3002-4367)
- Hui Li (ORCID: https://orcid.org/0000-0002-6362-3753)
- Pengfei Zhang (ORCID: https://orcid.org/0000-0003-4306-7961)
- Junqiu Liu (ORCID: https://orcid.org/0000-0002-8922-454X)
- Yue Ma (ORCID: https://orcid.org/0009-0009-5934-4207)
- Lei He (ORCID: https://orcid.org/0000-0003-2404-1774)
- Shengda Liu
- Jiayun Xu
- Feihu Yang
Institutions
- Changchun University of Science and Technology (CN)
- Hangzhou Normal University (CN)
- Open University of Israel (IL)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1002/anie.2025-m0501054600
- Primary Topic
- Photochromic and Fluorescence Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00