Five differentially expressed proteins identified to serve as potential blood biomarkers for schizophrenia screening based on proteomics
Our research indicates that neural cell adhesion molecule L1, integrin alpha-M, alpha-actinin-1, filamin-A and profilin-1 which are associated with cytoskeleton, synapse and immunity were preliminarily screened as candidate protein markers for schizophrenia. Moreover, mitogen-activated protein kinase signaling pathway may be related to the pathology of schizophrenia, and PI3K-Akt signaling pathway may be related to the efficacy and side effects of antipsychotic drugs.
Authors
- Lin Yang (ORCID: https://orcid.org/0000-0002-7594-3770)
- Xiaojia Fang
- Xiangdong Du
- Xiao‐Bin Zhang
- Chuanwei Li (ORCID: https://orcid.org/0000-0001-5982-3237)
- Lian Yuan
- Guangya Zhang
- Ronghua Li
- Yaozhi Liu
- Xiaoqian Fu
Institutions
- North Sichuan Medical University (CN)
- Soochow University (CN)
- Suzhou Guangji Hospital (CN)
- Hangzhou Seventh Peoples Hospital (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fpsyt.2025.1697383
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Program of Suzhou