Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010
The antinociceptive effect was receptor selective and affected by sex and neuropathic condition. This was unexpected based on the drug ex vivo pharmacological profiles and emphasizes the shortcomings of cell-based approaches to reliably predict behavioural responses.
Authors
- Stéphane Doridot
- Perrine Inquimbert (ORCID: https://orcid.org/0000-0003-2625-1468)
- Frédéric Bihel (ORCID: https://orcid.org/0000-0002-4122-0929)
- Chantal Fitterer
- Dominique Massotte
- Milica Jesic
- François Daubeuf
- Susruta Majumdar (ORCID: https://orcid.org/0000-0002-2931-3823)
- Martine Schmitt
- Séverine Schneider (ORCID: https://orcid.org/0000-0003-1332-6088)
- Yannick Goumon
- Virgine Andry
- Sylvain Hugel
- Abdelfattah Faouzi
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Health Sciences and Pharmacy (US)
- Washington University in St. Louis (US)
- Laboratoire d'Innovation Thérapeutique (FR)
- Institut des Neurosciences Cellulaires et Intégratives (FR)
- Itron (France) (FR)
- Saint Louis University (US)
- Université de Strasbourg (FR)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1111/bph.70285
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00