Improved Prediction of Vancomycin Pharmacokinetics in Patients Receiving Continuous Renal Replacement Therapy Using a Novel Population Model Validated With Real-World Data

We developed a novel vancomycin popPK model for adult CRRT patients that outperformed published models in a large real-world hemodialysis data set. This model improved predictive performance for serum vancomycin prediction, suggesting its potential to improve target attainment based on model-informed precision dosing for hemodialysis patients.