Uncovering plasma protein biomarkers linked to depression: A differential abundance analysis and Mendelian randomization using large-scale data
Several plasma proteins were associated with depression and enriched in immune-inflammatory pathways, though causal evidence was limited. Their druggability underscores the repurposing opportunities for immune dysregulations related to depression.
Authors
- Elina Hyppönen (ORCID: https://orcid.org/0000-0003-3670-9399)
- David Stacey (ORCID: https://orcid.org/0000-0002-9392-9235)
- Anwar Mulugeta
- Iqbal Madakkattel
- Endeshaw Abebe
Institutions
- South Australian Health and Medical Research Institute (AU)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1016/j.jad.2025.121134
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00