Integrative bulk and single-cell transcriptomic analysis reveals COL1A2-driven ECM remodeling and focal adhesion signaling associated with the transition from non-muscle-invasive to muscle-invasive bladder cancer

Our results suggest that the COL1A2-ECM-FAK signaling axis plays a critical role in MIBC progression, and COL1A2 could serve as a potential biomarker and therapeutic target for muscle-invasive bladder cancer.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-05
DOI
https://doi.org/10.3389/fonc.2025.1716324
Citations
2
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
44.47
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article

Integrative bulk and single-cell transcriptomic analysis reveals COL1A2-driven ECM remodeling and focal adhesion signaling associated with the transition from non-muscle-invasive to muscle-invasive bladder cancer

Xinwei Liu, Weiguo Chen, Zhao Shan-chao, Ninghan Feng et al.
2 citations
Frontiers in Oncology
Single-cell and spatial transcriptomics
44.47
article

Integrative bulk and single-cell transcriptomic analysis reveals COL1A2-driven ECM remodeling and focal adhesion signaling associated with the transition from non-muscle-invasive to muscle-invasive bladder cancer

Xinwei Liu, Weiguo Chen, Zhao Shan-chao, Ninghan Feng, Yichen Lu, Menglu Li, Zhiqiang Chen, Yuwei Zhang, Yuhui Xue, Ke Wang
article en
2 citations

Abstract

Our results suggest that the COL1A2-ECM-FAK signaling axis plays a critical role in MIBC progression, and COL1A2 could serve as a potential biomarker and therapeutic target for muscle-invasive bladder cancer.

Frontiers in OncologyVol. 15
Qingdao University (CN), Jiangnan University (CN), Nantong University (CN), Soochow University (CN), Third Affiliated Hospital of Southern Medical University (CN), Affiliated Hospital of Qingdao University (CN), Wuxi No.2 People's Hospital (CN), First Affiliated Hospital of Soochow University (CN), Wuxi People's Hospital (CN), Southern Medical University (CN)
Good health and well-being
Openalex Percentile: Top 1%
Single-cell and spatial transcriptomics
44.47
DOIOpen Access PDFOpenAlex
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Integrative bulk and single-cell transcriptomic analysis reveals COL1A2-driven ECM remodeling and focal adhesion signaling associated with the transition from non-muscle-invasive to muscle-invasive bladder cancer — Xinwei Liu, Weiguo Chen, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS