Downregulation of OPCML is associated with activation of AKT signaling and aggressive phenotypes in glioblastoma cells

<i>OPCML</i> marks a neuron-leaning, less aggressive state and is associated with the regulation of PI3K-AKT-mTOR signaling in GBM. Loss of <i>OPCML</i> aligns with proliferative programs and a GBM-specific immune pattern. These data nominate <i>OPCML</i> as a prognostic marker and a surface-level modulator that could be leveraged alongside RTK/PI3K axis inhibitors in GBM.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-05
DOI
https://doi.org/10.3389/fonc.2025.1710073
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Downregulation of OPCML is associated with activation of AKT signaling and aggressive phenotypes in glioblastoma cells

Y. Liu, Zhuang Liu, Wenrui Wu, Chunhua Xu et al.
Frontiers in Oncology
Glioma Diagnosis and Treatment
article

Downregulation of OPCML is associated with activation of AKT signaling and aggressive phenotypes in glioblastoma cells

Y. Liu, Zhuang Liu, Wenrui Wu, Chunhua Xu, Bilin Lin, Wu Zhou
article en

Abstract

<i>OPCML</i> marks a neuron-leaning, less aggressive state and is associated with the regulation of PI3K-AKT-mTOR signaling in GBM. Loss of <i>OPCML</i> aligns with proliferative programs and a GBM-specific immune pattern. These data nominate <i>OPCML</i> as a prognostic marker and a surface-level modulator that could be leveraged alongside RTK/PI3K axis inhibitors in GBM.

Frontiers in OncologyVol. 15
Jiangxi University of Traditional Chinese Medicine (CN), Fujian Medical University (CN), Nanchang University (CN), First Affiliated Hospital of Jiangxi Medical College (CN), Jiangxi Provincial People's Hospital (CN), Second Affiliated Hospital of Nanchang University (CN), Hubei University of Arts and Science (CN), Jiangxi Chest Hospital (CN), First Affiliated Hospital of Fujian Medical University (CN), Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN), First Affiliated Hospital of Nanchang University (CN)
Openalex Percentile: Top 97%
Glioma Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Downregulation of OPCML is associated with activation of AKT signaling and aggressive phenotypes in glioblastoma cells — Y. Liu, Zhuang Liu, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS