NOX1 gene expression and hormonal alteration in hypothyroidism-associated female infertility

Hypothyroidism-associated infertility is characterized by combined endocrine imbalance and heightened oxidative stress. The strong discriminative ability and hormonal correlations of NOX1 expression suggest its potential use as a molecular biomarker to support infertility risk detection in thyroid-compromised women, providing a basis for oxidative-stress-targeted therapeutic strategies.

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Publication Details

Journal
Hormone Molecular Biology and Clinical Investigation
Published
2026-01-05
DOI
https://doi.org/10.1515/hmbci-2025-0075
Primary Topic
Thyroid Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

NOX1 gene expression and hormonal alteration in hypothyroidism-associated female infertility

J. Chalil, Narayanan Parameswaran, Viji Krishnan, Dinesh Roy Divakaran et al.
Hormone Molecular Biology and Clinical Investigation
Thyroid Disorders and Treatments
article

NOX1 gene expression and hormonal alteration in hypothyroidism-associated female infertility

J. Chalil, Narayanan Parameswaran, Viji Krishnan, Dinesh Roy Divakaran, Anbalagan Gnanavel, Kesavi Durairaj, Sundaresan Saravana Kumar, Jisha Anjali Madhavan Pillai, Priyanka Krishnan, Jayasudha Edatholath
article en

Abstract

Hypothyroidism-associated infertility is characterized by combined endocrine imbalance and heightened oxidative stress. The strong discriminative ability and hormonal correlations of NOX1 expression suggest its potential use as a molecular biomarker to support infertility risk detection in thyroid-compromised women, providing a basis for oxidative-stress-targeted therapeutic strategies.

Hormone Molecular Biology and Clinical Investigation
Centre For Development Studies (IN), Sri Ramachandra Institute of Higher Education and Research (IN), Jubilee Mission Medical College and Research Institute (IN), Meenakshi Academy of Higher Education and Research (IN), Sri Ramachandra Medical Centre (IN), Meenakshi Medical College Hospital and Research Institute (IN)
Gender equality
Openalex Percentile: Top 97%
Thyroid Disorders and Treatments
DOIOpen Access PDFOpenAlex
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NOX1 gene expression and hormonal alteration in hypothyroidism-associated female infertility — J. Chalil, Narayanan Parameswaran, et al. · Hormone Molecular Biology and Clinical Investigation (2026) | TGRS Research Map | TGRS