Emergence of PHMB Resistance in <i>Acanthamoeba castellanii</i> and Observations on Cross-Resistance to Other Frontline Therapeutics
These findings represent the first known laboratory-induced PHMB-resistant <i>Acanthamoeba</i> strains, raising concerns regarding the longevity of current therapeutic options and the potential for cross-resistance to alternative treatments. This highlights the need for clinical vigilance and further investigation into the molecular mechanisms of resistance to better inform treatment strategies.
Authors
- Fiona L. Henriquez (ORCID: https://orcid.org/0000-0002-5534-1019)
- Jamie Whitelaw (ORCID: https://orcid.org/0000-0001-6739-1032)
- Stuart Woods (ORCID: https://orcid.org/0000-0002-3798-2074)
- Ronnie Mooney (ORCID: https://orcid.org/0000-0003-2426-0600)
Institutions
- University of Strathclyde (GB)
- University of the West of Scotland (GB)
Publication Details
- Journal
- Current Eye Research
- Published
- 2026-01-04
- DOI
- https://doi.org/10.1080/02713683.2025.2607477
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00