Kv2.1 negatively regulates Reissner fiber development
Analysis of zebrafish mutants of Kv2.1 subunits (Kcnb1 and Kcng4b) revealed that Kv2.1 negatively regulates Scospondin production at several levels. These mutations have opposing effects on the transcript levels of several genes involved in Reissner fiber development (<i>sspo</i>, <i>lgals2</i>, and <i>chl1a/camel</i>), affect the subcommissural organ and microfilament formation, and impact Reissner fiber assembly.
Authors
- Vladimir Korzh (ORCID: https://orcid.org/0000-0002-6580-7986)
- Justyna Jędrychowska (ORCID: https://orcid.org/0000-0002-8266-178X)
- Ruchi P. Jain
- R. Rosa Amini
Institutions
- International Institute of Molecular and Cell Biology (PL)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fcell.2025.1720752
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie