Aberrant functional connectivity of the dorsolateral prefrontal cortex-nucleus accumbens during naturalistic stimulation in adolescent major depressive disorder

These findings suggest that DLPFC-NAc hyperconnectivity is a neural substrate of MDD in adolescents and may preferentially contribute to anxiety-related or somatization-related symptomatology rather than depressive mood or sleep disturbance.

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Publication Details

Journal
Frontiers in Psychiatry
Published
2026-01-05
DOI
https://doi.org/10.3389/fpsyt.2025.1705969
Primary Topic
Functional Brain Connectivity Studies
Type
article
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article

Aberrant functional connectivity of the dorsolateral prefrontal cortex-nucleus accumbens during naturalistic stimulation in adolescent major depressive disorder

Z. P. ZANG, Zhuo Xi, Zhi Yang, Yingzhe Zhao et al.
Frontiers in Psychiatry
Functional Brain Connectivity Studies
article

Aberrant functional connectivity of the dorsolateral prefrontal cortex-nucleus accumbens during naturalistic stimulation in adolescent major depressive disorder

Z. P. ZANG, Zhuo Xi, Zhi Yang, Yingzhe Zhao, Jing Liu
article en

Abstract

These findings suggest that DLPFC-NAc hyperconnectivity is a neural substrate of MDD in adolescents and may preferentially contribute to anxiety-related or somatization-related symptomatology rather than depressive mood or sleep disturbance.

Frontiers in PsychiatryVol. 16
Harbin Medical University (CN), Beijing Anding Hospital (CN), Peking University Shenzhen Hospital (CN), First Affiliated Hospital of Harbin Medical University (CN), Beijing Advanced Sciences and Innovation Center (CN)
Openalex Percentile: Top 97%
Functional Brain Connectivity Studies
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Aberrant functional connectivity of the dorsolateral prefrontal cortex-nucleus accumbens during naturalistic stimulation in adolescent major depressive disorder — Z. P. ZANG, Zhuo Xi, et al. · Frontiers in Psychiatry (2026) | TGRS Research Map | TGRS