IL-22-STAT3-CD155 axis in alveolar echinococcosis: a pivotal role in immune exhaustion and therapeutic potential
Our study demonstrates that the IL-22-STAT3-CD155 axis, mediated by macrophage-hepatocyte crosstalk, drives the establishment of an immune-exhaustive microenvironment during <i>E.m</i> infection. Mechanistically, macrophage-derived IL-22 induces CD155 upregulation in hepatocytes via IL-22RA1/STAT3 signaling. Critically, rIL-22BP blockade disrupts this axis, reversing the immunosuppressive cascade, restoring CD8<sup>+</sup> T-cell effector functions, and remodeling the immune microenvironment. This intervention ultimately enhances host-mediated clearance of <i>E.m</i>.
Authors
- X. Zhang
- Renyong Lin
- Jin Chu (ORCID: https://orcid.org/0000-0003-4606-6585)
- Junlong Xue
- Ning Yang (ORCID: https://orcid.org/0000-0002-6354-3534)
- Tuerganaili Aji
- Liang Li
- Hui Liu
- Xiaojuan Bi
- Guodong Lv
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1674904
- Citations
- 1
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 36.00