Association between interleukin-27 and suicidal ideation: a Mendelian randomization analysis and peripheral blood experimental study
There are genetic associations between IL-27 and suicidal ideation, which is biologically corroborated by elevated peripheral IL-27 levels in high-risk suicidal individuals, highlighting its potential as a clinically viable biomarker for assessing suicidal risk in depressive patients.
Authors
- Xiwen Hu (ORCID: https://orcid.org/0000-0003-3995-7670)
- Shengdong Wang (ORCID: https://orcid.org/0000-0002-8231-1341)
- Xuan Ju
- Chunyan Zhu
- Xiaowen Yin
- Zhonglin Tan
- Lingna Lu
Institutions
- Tongde Hospital of Zhejiang Province (CN)
- Hangzhou Seventh Peoples Hospital (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fpsyt.2025.1678780
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province