Comparative effects of a TLR7/8 agonist and doxorubicin on immune checkpoint modulation and apoptosis in 4T1 breast cancer cells
R848 and doxorubicin possess anti-proliferative and pro-apoptotic effects on 4T1 cells, doxorubicin effectively induces cell death and boosts immune checkpoint gene expression, while R848 fosters early apoptosis without raising checkpoint ligand expression.
Authors
- Abolghasem Ajami
- Saeid Taghiloo (ORCID: https://orcid.org/0000-0002-8813-6046)
- Mohsen Tehrani
- Nazanin Joudaki
Institutions
- Mazandaran University of Medical Sciences (IR)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102440
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00