Analysis of <scp>SCLC</scp> subtype markers ( <scp>ASCL1</scp> , <scp>NEUROD1</scp> , <scp>POU2F3</scp> , <scp>YAP1</scp> ), <scp>DLL3</scp> , <scp>OTP,</scp> and <scp>TTF1</scp> in 300 lung carcinoids and enteropancreatic neuroendocrine tumours
Unlike SCLC, lung carcinoids and EP-NETs completely lack the expression of POU2F3 and YAP1, which offers diagnostic applications. Our findings also nominate ASCL1 and NEUROD1 as site of origin markers for lung versus digestive NETs/carcinoids, respectively. Finally, the divergent expression of DLL3 in lung carcinoids and EP-NETs has therapeutic implications.
Authors
- Francis M. Bodd (ORCID: https://orcid.org/0000-0003-4704-9832)
- Rohit Thummalapalli (ORCID: https://orcid.org/0000-0002-8865-0299)
- Laura H. Tang (ORCID: https://orcid.org/0000-0001-5735-9354)
- Susan Armstrong (ORCID: https://orcid.org/0000-0001-5489-6365)
- Zeynep Tarcan (ORCID: https://orcid.org/0000-0002-5046-7536)
- Alissa J. Cooper (ORCID: https://orcid.org/0000-0001-9124-0082)
- Charles M. Rudin (ORCID: https://orcid.org/0000-0001-5204-3465)
- Andrew M. Bellizzi (ORCID: https://orcid.org/0000-0002-8264-6379)
- Irfan Khan (ORCID: https://orcid.org/0000-0002-2361-6882)
- Olca Basturk
- Marina K. Baine
- William D Travis
- Natasha Rekhtman
- Prithviraj Solanki
- Christina Wilson
- Jake June‐Koo Lee
- Jonathan Willner
- Rania Aly
Institutions
- Cleveland Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Iowa Hospitals and Clinics (US)
- Tan Tock Seng Hospital (SG)
Publication Details
- Journal
- Histopathology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1111/his.70081
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Molecular Biology Laboratory
- National Cancer Institute