Yellow Nail Syndrome Presenting With a Complete Clinical Triad: A Report of a Rare Case

Yellow nail syndrome (YNS) is a rare disorder characterised by a triad of yellow nail discoloration, lymphoedema, and respiratory manifestations, including recurrent pleural effusions. A few hundred cases have been reported worldwide. Diagnosis is primarily clinical, as no definitive biomarkers exist, and the complete triad is seen in only a minority of patients. We report a 76-year-old male who presented with recurrent pleural effusions, non-pitting lower-limb oedema, and characteristic nail changes. Timely recognition of the classical triad allowed appropriate intervention, including indwelling pleural catheter placement and talc pleurodesis, leading to symptomatic improvement. This case highlights the importance of clinical vigilance in evaluating unexplained pleural effusions in older adults.

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Publication Details

Journal
Cureus
Published
2026-01-05
DOI
https://doi.org/10.7759/cureus.100801
Primary Topic
Lymphatic Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Yellow Nail Syndrome Presenting With a Complete Clinical Triad: A Report of a Rare Case

Esra M. Mustafa, Md Shamsuzzaman, Mubina Ahmed, Kazi Azad
Cureus
Lymphatic Disorders and Treatments
article

Yellow Nail Syndrome Presenting With a Complete Clinical Triad: A Report of a Rare Case

Esra M. Mustafa, Md Shamsuzzaman, Mubina Ahmed, Kazi Azad
article en

Abstract

Yellow nail syndrome (YNS) is a rare disorder characterised by a triad of yellow nail discoloration, lymphoedema, and respiratory manifestations, including recurrent pleural effusions. A few hundred cases have been reported worldwide. Diagnosis is primarily clinical, as no definitive biomarkers exist, and the complete triad is seen in only a minority of patients. We report a 76-year-old male who presented with recurrent pleural effusions, non-pitting lower-limb oedema, and characteristic nail changes. Timely recognition of the classical triad allowed appropriate intervention, including indwelling pleural catheter placement and talc pleurodesis, leading to symptomatic improvement. This case highlights the importance of clinical vigilance in evaluating unexplained pleural effusions in older adults.

CureusVol. 18(1)
South Essex Partnership University Foundation NHS Trust (GB), Mid Essex Hospital Services NHS Trust (GB)
Good health and well-being
Openalex Percentile: Top 97%
Lymphatic Disorders and Treatments
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