Necessity of Notch3 signaling in myofiber maturation in a pluripotent stem cell transplant model
Taken together, these findings demonstrate that Notch3 signaling is required for myofiber maturation, and that constant activation of Notch3 impairs proliferation and muscle regeneration. Transcriptional profiles of N3OE donor-derived satellite cells suggest that dampened regeneration may be driven by inhibitory alterations in cell cycle regulation.
Authors
- Sarah B. Crist
- Darko Bosnakovski (ORCID: https://orcid.org/0000-0002-7198-2019)
- Hyunkee Kim (ORCID: https://orcid.org/0009-0001-2457-2041)
- Phablo Abreu (ORCID: https://orcid.org/0000-0002-4143-6949)
- Bayardo I. Garay (ORCID: https://orcid.org/0000-0002-1458-6095)
- Karim Azzag
- Aaron Ahlquist
- Juan Abrahante
- Sergio H. D. M. Faria
- Aline M. S. Yamashita
- Rita C. R. Perlingeiro
Institutions
- University of Minnesota (US)
- Minneapolis Heart Institute Foundation (US)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s13395-025-00403-4
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00