The ectopic olfactory receptor OR7A17 regulates the proliferation and differentiation of human epidermal keratinocytes, and ginsenoside Rh3 acts as its antagonist
In summary, OR7A17 promoted keratinocyte proliferation by activating PKA/MAPK, Ca<sup>2+</sup>/CREB, and PI3K-AKT-NF-κB pathways, while repressing differentiation. In addition, ginsenoside Rh3 functioned as an antagonist of OR7A17, counteracting these effects. These findings suggest OR7A17 as a therapeutic target for proliferation- and differentiation-related skin disorders such as atopic dermatitis, with ginsenoside Rh3 as a potential regulator for epidermal homeostasis.
Authors
- Eunbi Yu (ORCID: https://orcid.org/0009-0008-2939-7167)
- Gyeonghyeon Kim (ORCID: https://orcid.org/0009-0001-4322-8932)
- Iseul Jo (ORCID: https://orcid.org/0000-0002-4258-9357)
- Koo Chul Kwon (ORCID: https://orcid.org/0000-0002-5161-4534)
- Su Bin Han
- Jae Youl Cho
- Sae Woong Oh (ORCID: https://orcid.org/0009-0008-3550-7027)
- In Ki Hong
- Soyoon Baek
- Hyeyoun Kim
- Seokhyeon Min
- Jongsung Lee
- Yeonsoo Kim
Institutions
- Konkuk University (KR)
- STR Biotech (South Korea) (KR)
- Kolmar Korea (South Korea) (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1016/j.jgr.2025.100972
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00