Targeting the DNA damage response prevents regrowth of colorectal peritoneal metastasis-derived organoids following treatment with mitomycin C
PMDOs can be completely eradicated if MMC treatment is followed by inhibition of ATR or other DDR kinases. DDR inhibitors may therefore have value in the adjuvant treatment of peritoneal metastases following CRS-HIPEC.
Authors
- Inne Borel Rinkes
- Kyah van Megesen (ORCID: https://orcid.org/0000-0003-0870-788X)
- Rebecca Amico
- Onno Kranenburg
- Anne M. L. Jansen
- Madelief Kieboom
- Arianna Stefan
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- University of Naples Federico II (IT)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1038/s41416-025-03310-z
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitair Medisch Centrum Utrecht