Chemogenetic Restoration of the “Excitation‐Inhibition” Imbalance in the Medial Prefrontal Cortex Ameliorates Schizophrenia‐Like Sensory Gating Deficits
We discovered that a disturbance in the "Excitation-Inhibition" balance in the mPFC significantly contributes to schizophrenia-like sensory gating deficits, cognitive impairments, and hyperlocomotion. Remarkably, correcting this imbalance in schizophrenia-like mice alleviated these deficits, providing profound insights into the regulatory functions of glutamatergic and GABAergic neurons in the mPFC.
Authors
- Huifeng Zhu (ORCID: https://orcid.org/0000-0003-3927-5151)
- Weihai Chen (ORCID: https://orcid.org/0000-0001-9551-321X)
- Lichun He
- Xiaoyu Chen
- Qiuxia Zhang
- Yanci Luo
- Yushan Cao
Institutions
- Southwest University (CN)
- Chongqing University (CN)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1111/apha.70151
- Primary Topic
- Neuroscience and Music Perception
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Southwest University
- Centre Scientifique et Technique du Bâtiment
- Fundamental Research Funds for the Central Universities