The neural correlates of illness awareness in addiction: a pilot exploratory analysis of preliminary data from the cognitive dysfunction in the addictions (CDiA) research program
The results of this pilot exploratory study cautiously suggest that similar to other conditions that feature impaired illness awareness, subjective addiction awareness may be related to increased frontoparietal and insular brain activity during an fMRI illness awareness task. However, no findings were significant after correction for multiple testing, hence, further study in a larger sample is required to establish brain regions associated with subjective substance use awareness.
Authors
- G Remington
- Fumihiko Ueno (ORCID: https://orcid.org/0000-0002-2547-7943)
- Jianmeng Song (ORCID: https://orcid.org/0000-0001-8223-8845)
- Anthony C. Ruocco (ORCID: https://orcid.org/0000-0002-1942-7181)
- Lena C. Quilty (ORCID: https://orcid.org/0000-0003-0934-4363)
- Daniel Felsky (ORCID: https://orcid.org/0000-0003-1831-9848)
- Shannon Lange (ORCID: https://orcid.org/0000-0003-3907-6072)
- Daphne Voineskos (ORCID: https://orcid.org/0000-0002-7450-4434)
- Yuliya S. Nikolova (ORCID: https://orcid.org/0000-0001-5144-3723)
- Antonio P. Strafella
- Etienne M. Sibille
- Shannen Kyte (ORCID: https://orcid.org/0009-0008-0842-8411)
- Edgardo Carmona-Torres
- Danielle Bukovsky
- Sri Mahavir Agarwal
- Philip Gerretsen
- Erica Vieira
- Aron Amaev
- Thomas D. Prevot
- Ariel Graff-Guerrero
Institutions
- University Health Network (CA)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Scarborough Health Network (CA)
- Public Health Ontario (CA)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fneur.2025.1694826
- Primary Topic
- Spatial Neglect and Hemispheric Dysfunction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centre for Addiction and Mental Health Foundation
- University of Toronto
- Krembil Foundation
- Department of Psychiatry, University of Toronto
- Canadian Institutes of Health Research