Metformin attenuates PTZ-Induced seizures and cognitive impairment and is associated with altered NOS/NO signaling: combined <i>in vivo</i> and in silico evidence

Metformin exerted seizure-suppressing and cognition-preserving effects in an acute PTZ model, associated with reductions in NOS isoform expression and NO levels, suggesting altered NOS/NO signaling and supporting its potential as an adjunctive candidate for mitigating seizure-related neuronal dysfunction.