Comparison of granule and traditional decoction of Gancao Xiexin for cold-heat complex pattern recurrent oral ulcer: a randomized controlled trial
GXD granules and traditional decoction showed comparable clinical efficacy in managing ROU with cold-heat complex syndrome. Notably, granule formulations exhibited lower heavy metal content, suggesting potential advantages in safety profile.
Authors
- Sirun Liu (ORCID: https://orcid.org/0000-0002-6567-524X)
- Huachong Xu (ORCID: https://orcid.org/0000-0003-4046-7599)
- Ruixue Wang (ORCID: https://orcid.org/0000-0002-8772-4954)
- Zejian Li (ORCID: https://orcid.org/0000-0002-7039-0601)
- Ya Zeng
- H -J Zhu
- Pei-Chi Chen
Institutions
- Jinan University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fphar.2025.1668985
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00