Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model
CTX/PMB showed therapeutic potential in treating PC-R K. pneumoniae. However higher CTX doses may potentiate PMB-associated toxicity. These findings encourage further investigation in advanced preclinical models and clinical settings to fully elucidate CTX/PMB therapeutic potential and optimize dosing regimens.
Authors
- Ediane Bortolotte Cornelius
- Mariana Carvalho Sturaro (ORCID: https://orcid.org/0009-0003-0455-9258)
- Osmar Nascimento Silva (ORCID: https://orcid.org/0000-0003-2148-131X)
- Thiago Leite Fraga (ORCID: https://orcid.org/0000-0003-2820-194X)
- Simone Simionatto (ORCID: https://orcid.org/0000-0003-2367-0915)
- Luana Rossato (ORCID: https://orcid.org/0000-0002-6115-3313)
- Gleyce Hellen de Almeida de Souza (ORCID: https://orcid.org/0000-0001-8860-9109)
- Nathalia da Silva Damaceno
- J. Echeverría
- Pedro Vinícius Dias Bassetto Silva
- Luccas Pereira Pires
- Bárbara Maria Cristaldo Gomes
Institutions
- Universidade Federal da Grande Dourados (BR)
- Universidade Estadual de Goiás (BR)
- Centro Universitário da Grande Dourados (BR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1371/journal.pone.0339990
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00