Glutamate enhances the production of inflammatory cytokines IL-6 and IL-11, as well as chemokines CXCL2, CXCL3, and CXCL8 in keloid fibroblasts
These results underscore the crucial role of glutamate metabolism in promoting the infammatory functions of fbroblasts. They suggest that glutamate contributes to keloid progression and provides a theoretical basis for targeting glutamte signaling pathway in keloid treatment.
Authors
- Jiang Zhu
- Jiahe Zhang (ORCID: https://orcid.org/0009-0005-7938-7707)
- Y M Song
- Hao Cheng
- Jie Chen
- Yan Chen
- Chenxi Feng
- Jing Pan
- Yaohan Xu
Institutions
- Sir Run Run Shaw Hospital (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fmolb.2025.1720876
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Natural Science Foundation of Zhejiang Province