Integrating single cell- and spatial- resolved transcriptomics unravels the inter-tumor heterogeneity and immunosuppressive landscape in HBV- and Clonorchis sinensis-associated hepatocellular carcinoma
These findings decipher the cellular signatures and their interactions within the TME, shedding light on the inter-tumoral heterogeneity driven by different infections, and the development of targeted therapies for infectious HCC.
Authors
- Guangqing Cheng
- Xiwen Liao (ORCID: https://orcid.org/0000-0002-2349-8775)
- Yanni Lou
- Guodong Lü (ORCID: https://orcid.org/0009-0004-8833-5071)
- Guangzhi Zhu
- Junqi Liu
- Jigang Wang
- Liqun Jia
- Jiayun Chen
- Ji Feng
- Jing Liu
- Tao Peng
- Yunmeng Bai
- Wenmin Lu
- Zhaoji Liu
- Jing Zhou
Institutions
- Guangxi Medical University (CN)
- Guangdong Pharmaceutical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- China-Japan Friendship Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s12943-025-02381-z
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00