Adjuvant IL-15 Blockade Significantly Improves Survival in a CD28-based Immunosuppression Protocol of Pig-to-nonhuman Primate Renal Xenotransplantation
These findings deepen our understanding of NK cell subsets and their potential contributions to xenograft injury and suggest that targeted modulation of NK cell populations can enhance xenograft outcomes in a preclinical pig-to-rhesus macaque model of renal xenotransplantation.
Authors
- Joe B. Jenkins
- Ian N. Moore (ORCID: https://orcid.org/0000-0002-0391-6466)
- Steven C. Kim (ORCID: https://orcid.org/0000-0001-8221-8043)
- J. Keiler (ORCID: https://orcid.org/0000-0002-0151-755X)
- Kristin M. Whitworth (ORCID: https://orcid.org/0000-0001-9959-108X)
- William H. Kitchens (ORCID: https://orcid.org/0000-0001-7835-8393)
- Andrew B. Adams (ORCID: https://orcid.org/0000-0001-8925-9956)
- Mandy L. Ford (ORCID: https://orcid.org/0000-0001-6736-4421)
- C P Larsen
- R. Paul Johnson
- Bobbi J. Wilson
- Jakob G. Habib
- A. Brad Farris
- Lizheng Guo
- Ji W. Han
Institutions
- University of Minnesota (US)
- Emory University (US)
- University of Missouri (US)
Publication Details
- Journal
- Transplantation
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1097/tp.0000000000005608
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 0.00