Decidual stromal cells drive CD16+ macrophages towards an immunoregulatory phenotype via extracellular matrix-adhesion molecule interaction during early pregnancy
This study confirms that DSC can regulate the immune status of CD16<sup>+</sup> dMφ through the ECM-adhesion molecule axis, further elucidating the regulatory mechanisms of Mφ during decidualization. Exploration of therapeutic strategies based on ECM-receptor-mediated stroma-immune interactions holds promise as novel treatment approaches for miscarriage.
Authors
- Shi Jia-wei
- Ting Peng (ORCID: https://orcid.org/0000-0001-6566-0454)
- J. D. Ye
- Li Wang (ORCID: https://orcid.org/0000-0002-4206-0285)
- Hongbo Zhao (ORCID: https://orcid.org/0000-0002-6350-3401)
- Zhen-Zhen Lai
- Ming-qing LI
- Hui-Li Yang
- Xin Li
- Chun-Jie Gu
- Zi-Meng Zheng
Institutions
- Agency for Science, Technology and Research (SG)
- Fujian Medical University (CN)
- Shanghai Changning Maternity and Infant Health Hospital (CN)
- Singapore Institute for Clinical Sciences (SG)
- International Peace Maternity & Child Health Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Ningbo University Affiliated Hospital (CN)
- Union Hospital (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1747323
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- National Key Research and Development Program of China