Trace Detection of Ibuprofen in Solution Based on Surface Plasmon Resonance Technology

A surface plasmon resonance (SPR) sensor utilizing a molecularly imprinted polymer (MIP) film as the recognition element was developed for the selective detection of the non-steroidal anti-inflammatory drug ibuprofen (IBU). The molecularly imprinted film on the SPR sensor chip was prepared via photo-initiated in situ polymerization, enabling specific recognition of IBU molecules. Experimental results indicate that the SPR sensor can specifically identify IBU in solution, with a detection limit of 10−11 mol/L for ibuprofen. Within the concentration range of 10−11 to 10−4 mol/L, a linear relationship was observed between the SPR signal and the negative logarithm of the IBU concentration. This method offers the advantages of a low detection limit, wide detection range, and high selectivity, making it suitable for trace detection of IBU in solutions.