Neonatally-derived multipotent Islet-1+ Mesp1+FOXA2+ stem cell clones restore cardiac function in sheep
<i>ISL1</i>+ <i>MESP1</i>+ <i>FOXA2</i>+ stem cell clones isolated from neonatal cardiovascular tissue represent a novel resource of cells with the capacity to restore cardiac function following myocardial infarction in a preclinical large animal model.
Authors
- Danielle Yanez
- Kearns-Jonker Mary
- Jonathan Baio
- Victor Camberos (ORCID: https://orcid.org/0000-0003-1587-4539)
- Alicia L. Veliz (ORCID: https://orcid.org/0000-0003-2529-7181)
- Nahidh Hasaniya
- Lorelei Hughes (ORCID: https://orcid.org/0000-0002-4056-3292)
- Richard Vega
- Leonard L. Bailey
- Edward Austin
- Christopher G. Wilson
- Julia Kim
- Paola Rivera Morales
Institutions
- Loma Linda University Medical Center (US)
- Loma Linda University (US)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fcvm.2025.1671367
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- California Institute for Regenerative Medicine
- Loma Linda University