Antioxidants rescue murine mesangial cells from docosahexaenoic acid-induced ferroptosis
Our results provide evidence that DHA-treatment alone may have detrimental effects in susceptible cells, which could partially explain inconsistent results of clinical studies. This emphasizes the importance of a balance between pro- and anti-ferroptotic mechanisms in therapeutic strategies using n-3 PUFAs to promote kidney health.
Authors
- Jenny Voggel (ORCID: https://orcid.org/0000-0001-9120-2203)
- Eva Nüsken (ORCID: https://orcid.org/0000-0002-0674-804X)
- Maria Wohlfarth
- Gregor Fink (ORCID: https://orcid.org/0000-0001-7042-1706)
- Lea Quell (ORCID: https://orcid.org/0000-0002-4400-3129)
- Leon Saschin (ORCID: https://orcid.org/0000-0002-9002-1600)
- Miguel A Alejandre Alcázar
- Jörg Dötsch
- Anna Kowalewski
- Kai-Dietrich Nüsken
Institutions
- University of Cologne (DE)
- German Center for Lung Research (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Molecular and Cellular Pediatrics
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s40348-025-00215-y
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00