Safety and Tolerability of Single and Multiple Daily Oral Doses of Dried Kratom Leaf Powder in a Randomized Trial in Healthy Volunteers
This SD and first MD controlled study shows that Mitragyna speciosa-derived MitraLeaf kratom powder was safe and well tolerated at the dose ranges tested, with no evidence of meaningful abuse potential or withdrawal.
Authors
- Sibyl N. Swift
- Jack E. Henningfield (ORCID: https://orcid.org/0000-0001-8387-0041)
- Thomas J. Hudzik (ORCID: https://orcid.org/0000-0002-3982-4475)
- John Bothmer
- Marilyn A. Huestis
Institutions
- Univates (BR)
- Thomas Jefferson University (US)
- UCB Pharma (United States) (US)
- Octapharma (United States) (US)
- UCB Pharma (Netherlands) (NL)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1097/ftd.0000000000001427
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00