Protective effect of Lactococcus lactis NZ9000 secreting Bcl2 against Trichinella spiralis infection in mice
Recombinant L. lactis secreting Bcl2 confers partial protection against T. spiralis by enhancing mucosal barrier function and modulating host immunity. These findings highlight the potential of engineered probiotics as a novel platform for antiparasitic intervention, offering translational relevance for food safety and zoonotic disease control.
Authors
- Suxian Liu
- L Wang
- Jiyuan Shen (ORCID: https://orcid.org/0009-0007-3905-0426)
- H. T. Zhang
- Lan Wei
- Yixin Lu
- Yukai Lin
- Huarun Sun
- Yuanfang Ma
- Siyang Li
- Doudou Feng
- Ruibiao Wang
- Bo Wen (ORCID: https://orcid.org/0000-0002-3839-2391)
- Minghui Li
Institutions
- Northeast Agricultural University (CN)
- Zhengzhou University (CN)
- Henan University of Engineering (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Henan Institute of Science and Technology (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1186/s12917-025-05238-1
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00