Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome
Through in-depth transcriptional analysis we identify potential molecular targets that shed light on the mechanisms of TBI-induced microglial activity and reveal how SF after TBI alters this response. Together, these data could inform therapeutic strategies that target neuroinflammation to improve chronic recovery after brain injury.
Authors
- J SHERIDAN
- Amara C. Davis
- Christopher Cotter
- Zoe M. Tapp (ORCID: https://orcid.org/0000-0003-4961-2836)
- Morgan Taylor
- Samuel Houle (ORCID: https://orcid.org/0000-0002-4733-5823)
- Jonathan P Godbout
- Rebecca Boland
- Olga N. Kokiko-Cochran
Institutions
- Institute for Behavioral Medicine (US)
- The Ohio State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.3389/fimmu.2025.1689773
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Miami
- Ohio State University
- National Institute of Neurological Disorders and Stroke